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The FDA has cleared ziprasidone (Geodon) for maintenance treatment of bipolar I disorder as an adjunct to lithium or valproate.
Chronic schizophrenia patients exhibit robust MMN deficits, while MMN reduction in first-episode and early phase psychosis is significantly less consistent.
Additional secondary endpoints included changes in scores on the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impres sions Improvement and Severity Scales (CGI-I and CGI-S), the Calgary Depression Scale for Schizophrenia (CDSS), the Schizophrenia Cognition Rating Scale (ScoRS), and the Global Assessment of Functioning (GAF).
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The study by Mathes et al investigated 55 patients with schizophreniform psychosis, 50 patients with established schizophrenia, and a control group of 56 healthy controls, using the delayed matching-to-sample task from the Cambridge Neuropsychological Test Automated Battery (CANTAB).
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Cortical surface is expected to be relatively stable over time and correlated to premorbid IQ measured at baseline.
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Each practice guideline is extensively reviewed at multiple draft stages.
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This study sought to examine longitudinal relationships between intrinsic motivation and substance use severity in a sample of patients with comorbid SUD and schizophrenia.
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Hettema J, Prescott C, Meyers J, et al: The structure of genetic and environmental risk factors for anxiety disorders in men and women.
Such disease genes can be difficult to find without very large sample sizes, on the order of thousands of subjects.
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Cannabis use was associated with more significant reductions of the hippocampus in individuals with FEP and its use may be associated with additional deleterious structural brain abnormalities.
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Concomitant use of IM and oral preparations in schizophrenic patients is not recommended.
Unanswered questions from this study include the respective roles of first-generation and second-generation antipsychotic medications and when clozapine should be used.
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Similar to other chronic illnesses, children and adolescents with SCD engage in a greater number of daily adaptive tasks, particularly medical self-care tasks, compared.
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Low AF may represent a modifiable risk factor for neurocognitive dysfunction in schizophrenia for which AE training offer a novel, non-stigmatizing, side-effect-free intervention to ameliorate such deficits.
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As more information becomes available from long term prospective cohort studies, we expect this evidence can be used to inform practice.
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Item response theory (IRT) strategies; 2) Uses dynamic-titration feedback from immediate task performance to adjust the difficulty of task performance; and 3) Provides immediate trial by trial feedback and, most critically, instructional responses following errors, followed by repetition of the previously failed item.
The use of neuroleptic agents is contraindicated in comatose patients and patients with severe central nervous system depression.
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Initial data support a significant decrease in preventable hospital readmissions, and a 85% follow through with first prescriber appointments after the intake process.
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Results: There were no significant differences between LAI_R and oral SGA treatment in time to first relapse and hospitalization.
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Treatment of akathisia can include a dosage reduction when possible, or the addition of a low-dose beta blocker, such as propranolol (Inderal) at 20 to 80 mg per day.
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An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder.
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Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials.
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Results: Parental history of psychosis did not confound the association between childhood adversity and psychotic disorder.
These trials ranged in duration from three to eight weeks.
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After a 3-day single-blind placebo run-in, subjects were randomized to one of 3 fixed doses of ziprasidone (20 mg, 40 mg, or 80 mg twice daily) or placebo and observed for relapse.
However, haloperidol, while helpful for reducing symptoms of aggression, can also have adverse side effects, such as sedation, muscle stiffness, and abnormal movements.
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From these data I conclude, for now: aripiprazole does probably have an antidepressant effect for some people, so it is still worth thinking about as a candidate treatment for bipolar depression, even though the data did not officially support this approach by the usual standard.
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IL-6 levels significantly decreased following treatment for acute depression.
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Methods: Sixteen participants (8 SZ and 8 HC) were exposed to the Trier Social Stress Test.
Only WAIS measures of general verbal ability and IQ, in contrast to negative symptoms or cognitive functioning in particular domains, significantly predicted work functioning eight years later.
Conclusion: These findings bolster support for the presence and functional significance of impaired cognitive empathy in schizophrenia using a contemporary measure of empathy.
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Conclusion: These results suggest that patients with schizophrenia recruit a similar network as controls for attributing mental states.
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We assess the interaction between schizophrenia-associated genes (such and NRG1 and CHRNA7), environment (such as prenatal anxiety) and interventions (such as perinatal choline supplementation) on the development of cerebral inhibition (P50 sensory gating and mismatch negativity) and behavior.
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Here, we first explored the FAERS database to determine an effective drug combination to lower the occurrence of antipsychotic-induced hyperglycaemia, and then ascertained the validity of the prospective drug combination in a mouse model of antipsychotic-induced glucose intolerance.
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With few exceptions, further statistically significant improvement compared to placebo was observed at each subsequent weekly assessment in both ziprasidone treatment groups.
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Epigenetics describes the study of mitotically heritable alterations in gene expression potential that are not caused by changes in DNA sequence ().
The last strategy is a combination treatment with a second antipsychotic.
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Geodon belongs to a group of medications called atypical antipsychotics that work by lessening the effects of dopamine and serotonin in the brain that are typically elevated in patients with schizophrenia or bipolar disorder.
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Both schizophrenia-spectrum and bipolar disorders appear to be associated with a dysregulated hypothalamic-adrenal-pituitary axis (HPA).
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Systemic Bioavailability: The bioavailability of ziprasidone administered intramuscularly is 100%.
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These findings enhance our understanding of how this critical region of the brain might play a role in SZ and how glutamatergic and dopaminergic abnormalities may interact in SZ.
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Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III.
The medication increases the number of satisfying sexual events per month by about one half over placebo from a starting point of about two to three.
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Future studies should investigate methods for improving treatment adherence to training, whether booster session can increase maintenance of cognitive gains, and whether combination with evidence-based psychosocial interventions more strongly improves real-world functioning and long-term outcomes.
New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis.
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Ziprasidone blocks wild-type hERG current in a voltage- and concentration-dependent manner with IC(50) of 120nM in stably transfected HEK-293 cells.
Social or nonsocial events were presented, followed by the addition of context: congruent context was designed to confirm a spontaneous inference (about the cause of the event), and incongruent context was to provoke an adaptation of the inference.
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Despite the improvements in subject weight observed during these trials, it still remains unclear whether such gains would be maintained over longer periods of time.
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In women with psychotic disorders, this may be clinically relevant as the presence of methylation may further impair social cognition that is already impaired in the disorder.
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Olanzapine could be a reasonable choice in a woman who had a history of good response to this medication, but would be lower priority than quetiapine when a new drug is indicated during pregnancy.
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