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At this point, ablation is not recommended as a first line treatment.

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Patients were eligible for inclusion if they had had a myocardial infarction, had undergone placement of an ICD, and had had an episode of ventricular tachycardia during treatment with amiodarone or another class I or class III AAD within the previous 6 months.

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Episodes of ventricular tachycardia were defined as any one of the following: three or more episodes of ventricular tachycardia treated with antitachycardia pacing, of which at least one episode was symptomatic; one or more appropriate ICD shocks; three or more episodes of ventricular tachycardia within 24 hours; or sustained ventricular tachycardia at a rate below the programmed detection rate of the ICD.

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Sotalol is not approved for use in children, as there is not enough research to demonstrate that it is safe and effective for this age group.

Doyle, LW; Crowther, CA; Middleton, P; Marret, S; Rouse, D (Jan 21, 2009).

Catheter ablation has become the preferred therapy, over long-term pharmacologic therapy, for management of patients with AVNRT.

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The effect of cardioversion on exercise capacity in patients with atrial fibrillation.

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These studies, however, do not demonstrate that amiodarone is superior to class Ic antiarrhythmic agents or sotalol.

During premarketing trials, 3186 patients with cardiac arrhythmias (1363 with sustained ventricular tachycardia) received oral Sotalol, of whom 2451 received the drug for at least two weeks.

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After a mean follow-up of 21 plus or minus 11 months, only 36% of patients treated with drugs compared with 80% of those treated with catheter ablation remained in sinus rhythm.

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ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation.

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Although sotalol is usually well-tolerated hemodynamically, in patients with marginal cardiac compensation, deterioration in cardiac performance may occur.

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My question is can I give him benadryl for is itchy skin if he other medications.

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If you do miss a dose, skip the missed dose and take only the next regularly scheduled dose.

At the highest dose of dofetilide tested (500 μg twice per day), maintenance of sinus rhythm more than or equal to 350 days occurred in 73% of patients with atrial flutter compared with 40% of patients with AF.

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Information says it is a rare side effect.

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In a randomized, clinical trial, a repeat pulmonary vein isolation procedure was more effective than the use of antiarrhythmic drugs in preventing recurrences of paroxysmal AF.

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DO NOT skip a dose unless you are told to.

Talk with the doctor if your child has a long QT on ECG.

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Age per se does not significantly alter the pharmacokinetics of Sotalol, but impaired renal function in geriatric patients can increase the terminal elimination half-life, resulting in increased drug accumulation.

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Sotalol hydrochloride, is an antiarrhythmic drug with Class II (beta-adrenoreceptor blocking) and Class III (cardiac action potential duration prolongation) properties.

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The MEA also helps determine the nature of aberrant conduction disturbances (so called bundle branch block).

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Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease.

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Anyone with a condition affecting the heart that can cause sudden cardiac death needs to take extra care with medicines.

No: Patient did not received weight management treatment.

Verapamil and metoprolol do not affect conduction in the AV bypass tract (may slow Mahaim fibers or atriofascicular pathway conduction).

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Azithromycin and levofloxacin use and increased risk of cardiac arrhythmia and death.

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The 2006 Heart Failure Society of America guidelines take the position that in heart failure patients, class III agents may decrease the frequency of ventricular arrhythmias but may also carry an increased risk of adverse events without significant benefit.

In several studies, risk factors for development of embolic events were similar to those described for AF.

Its interactions with these receptors in the central nervous system apparently mediate most of its pharmacologic effects, including analgesia.

The presence of other medical problems may affect the use of this medicine.

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Postoperative AF was reduced by treatment with Landiolol hydrochloride.

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The deleterious effects of excessive right ventricular pacing vs right ventricular backup pacing only in patients with dual-chamber devices and ICD indications were made apparent in trials such as The Dual Chamber and VVI Implantable Defibrillator (DAVID) trial.

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However, of necessity, examples cited and advice given must be general in nature and may not apply to any particular case.

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FDA approval process, including medical reviews and correspondence letters.

ESC guidelines recommend exercise testing to provoke ischemic changes or ventricular arrhythmias.

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Gi signs are the common noncardiac adverse effect and are more common in cats, especially with sustained-release preparations.

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The whole manufacturing process is regulated by the US Food and Drug Administration (FDA) and other relevant authorities.

Some nerve and muscle disorders also can cause heart block, including muscular dystrophy.

Current practice constraints mandate that clinicians carefully consider patient populations at low and acceptable risks for outpatient antiarrhythmic drug initiation.

ABCs as well as placement of the patient on a cardiac monitor with automated BP cuff, continuous pulse oximetry monitoring, provision of supplemental oxygen as needed, and establishment of intravenous access.

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Indacaterol produced statistically improved FEV 1 (both trough and AUC) and decreased use of rescue medication compared to placebo, but with safety and tolerability similar to those of placebo.

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The ultimate goal of these therapies is also likely to evolve beyond the conventional metric of time to first AF recurrence.

HRS Guideline for the Management of Patients With Atrial Fibrillation provides additional insight into the application of the CHADS2-VASc in clinical practice.

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All patients with severe symptoms, such as syncope or dyspnea, during palpitations should also be referred for prompt evaluation by an arrhythmia specialist.

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However, in cases where standard deviations were not reported, the standard error was calculated if the p values or 95% CIs were reported and meta-analysis was undertaken with the mean and standard error (SE) using the generic inverse variance method in RevMan5.

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If these conditions occur, infusion of the drug should be discontinued, or the rate of infusion should be reduced.

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In approximately 60% of patients, atrial flutter occurs as part of an acute disease process, such as exacerbation of pulmonary disease, postoperative cardiac or pulmonary surgery, or during acute myocardial infarction.

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Hypotension, bradycardia with reserpine, guanethidine, other catecholamine-depleting drugs.

The percentages of patients who had predictions of drug efficacy and who had adverse effects during treatment were compared by standard statistical tests for categorical and continuous data.

Neither of the two study treatments showed superiority with respect to mortality, perhaps because of the relatively high risk of death from nonarrhythmic causes.

REVIEW: Management of Ventricular Tachycardia in Patients with Structural Heart Disease.

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These guidelines are intended to help clinicians tailor antiarrhythmic therapy on an individual basis for their patients.

Guidelines are official policy of both the ACC and AHA.

This makes symptomatic bradycardia or hypotension unlikely to be the cause of the decline in β-blocker therapy in the sotalol group.

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Because of the long terminal elimination half-life of SOTALOL, dosing on more than a BID regimen is usually not necessary.

Patients taking phenobarbital, phenothiazine tranquilizers (chlorpromazine, perphenazine, fluphenazine, etc.

During follow-up, sustained ventricular tachyarrhythmias were considered to be recurrences of arrhythmia rather than proarrhythmic effects, except for torsade de pointes, which was tabulated as a recurrence of arrhythmia in the actuarial analyses and a proarrhythmic effect in the analysis of adverse events.

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