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Placebo controlled trial of single dose of albendazole, ivermectin or the combination of both in 1425 persons from filariasis-endemic villages; albendazole therapy was associated with a modest but delayed reduction in microfilarial levels; side effects were mild and self-limited and not different from placebo; no mention of jaundice or hepatitis).

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LCMS studies indicated that drug released from cAC10-L4-MMAF was the cysteine-L4-MMAF adduct, which likely arises from mAb degrdn.

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The range of effects with albendazole was: elevation of transaminases (5 patients), abdominal pain and other gastrointestinal symptoms (7 patients), severe headache (4 patients), loss of hair (2 patients), leucopenia (2 patients), fever and fatigue (1 patient), thrombocytopenia (1 patient), and urticaria and itching (1 patient).

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In addition to the citations given in our previous reviews covering these methodologies, there have been some recent publications that can be consulted in order to demonstrate how “privileged structures from Nature” are demonstrated sources of molecular skeletons around which one may build libraries.

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