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In addition, shows improvement in the WMD for the Clinical Dementia Rating scale, another measure of global function; however, the tests for heterogeneity were significant.

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In some studies, but not all, vitamin E (400 - 800 IU per day), combined with Aricept, helped slow cognitive decline in people with Alzheimer's disease.

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The primary scales used to measure the domain of cognition deficits were the Alzheimer's Disease Assessment Scale (ADAS) cognitive subscale (ADAS-cog), noncognitive subscale (ADAS-noncog), and total score (ADAS-tot); Mini-Mental State Examination (MMSE) or standardized MMSE; and the Severe Impairment Battery (SIB).

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